PUBLICATIONS

1. Effects of aerobic exercise training on cerebral pulsatile hemodynamics in middle-aged adults with elevated blood pressure/stage 1 hypertension. Reed KS, Frescoln AM, Keleher Q, Brellenthin AG, Kohut ML, Lefferts WK.J Appl Physiol (1985). 2024 Jun 1;136(6):1376-1387. doi: 10.1152/japplphysiol.00689.2023. Epub 2024 Apr 11.PMID: 38601998 Free PMC article.
2. Aerobic, resistance, or combined exercise training and cardiovascular risk profile in overweight or obese adults: the CardioRACE trial. Lee DC, Brellenthin AG, Lanningham-Foster LM, Kohut ML, Li Y.Eur Heart J. 2024 Apr 1;45(13):1127-1142. doi: 10.1093/eurheartj/ehad827.PMID: 38233024 Free PMC article. Clinical Trial.
3. Novel nanoadjuvants balance immune activation with modest inflammation: implications for older adult vaccines. Ross KA, Tingle AM, Senapati S, Holden KG, Wannemuehler MJ, Mallapragada SK, Narasimhan B, Kohut ML.Immun Ageing. 2023 Jun 21;20(1):28. doi: 10.1186/s12979-023-00349-5.PMID: 37344886 Free PMC article.
4. “Just right” combinations of adjuvants with nanoscale carriers activate aged dendritic cells without overt inflammation. Ananya A, Holden KG, Gu Z, Nettleton D, Mallapragada SK, Wannemuehler MJ, Kohut ML, Narasimhan B.Immun Ageing. 2023 Mar 9;20(1):10. doi: 10.1186/s12979-023-00332-0.PMID: 36895007 Free PMC article.
5. Mitochondrial Mass of Naïve T Cells Is Associated with Aerobic Fitness and Energy Expenditure of Active and Inactive Adults. Alley JR, Valentine RJ, Kohut ML.Med Sci Sports Exerc. 2022 Aug 1;54(8):1288-1299. doi: 10.1249/MSS.0000000000002914. Epub 2022 Apr 1.PMID: 35389948
6. Peripheral inflammatory cytokines and motor symptoms in persons with Parkinson’s disease. Diaz K, Kohut ML, Russell DW, Stegemöller EL.Brain Behav Immun Health. 2022 Mar 7;21:100442. doi: 10.1016/j.bbih.2022.100442. eCollection 2022 May.PMID: 35308082 Free PMC article.
7. Exercise after influenza or COVID-19 vaccination increases serum antibody without an increase in side effects. Hallam J, Jones T, Alley J, Kohut ML.Brain Behav Immun. 2022 May;102:1-10. doi: 10.1016/j.bbi.2022.02.005. Epub 2022 Feb 5.PMID: 35131444 Free PMC article.
8. Exercise duration modulates upper and lower respiratory fluid cellularity, antiviral activity, and lung gene expression. Elkhatib SK, Alley J, Jepsen M, Smeins L, Barnes A, Naik S, Ackermann MR, Verhoeven D, Kohut ML.Physiol Rep. 2021 Oct;9(20):e15075. doi: 10.14814/phy2.15075.PMID: 34676696 Free PMC article.
9. Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE): Rationale, design, and methods. Brellenthin AG, Lanningham-Foster LM, Kohut ML, Li Y, Church TS, Blair SN, Lee DC.Am Heart J. 2019 Nov;217:101-111. doi: 10.1016/j.ahj.2019.08.008. Epub 2019 Aug 15.PMID: 31520895 Free PMC article. Clinical Trial.
10. STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice. Darling RJ, Senapati S, Kelly SM, Kohut ML, Narasimhan B, Wannemuehler MJ.Vaccine. 2019 May 6;37(20):2721-2730. doi: 10.1016/j.vaccine.2019.04.004. Epub 2019 Apr 12.PMID: 30987850 Free PMC article.
11. Imoxin attenuates LPS-induced inflammation and MuRF1 expression in mouse skeletal muscle. Valentine RJ, Jefferson MA, Kohut ML, Eo H.Physiol Rep. 2018 Dec;6(23):e13941. doi: 10.14814/phy2.13941.PMID: 30548229 Free PMC article.
12. Association of Sleep Quality With Cardiovascular Disease Risk and Mental Health in Law Enforcement Officers. Everding B, Hallam JE, Kohut ML, Lee DC, Anderson AA, Franke WD.J Occup Environ Med. 2016 Aug;58(8):e281-6. doi: 10.1097/JOM.0000000000000814.PMID: 27414012
13. Is Insomnia a Risk Factor for Decreased Influenza Vaccine Response? Taylor DJ, Kelly K, Kohut ML, Song KS.Behav Sleep Med. 2017 Jul-Aug;15(4):270-287. doi: 10.1080/15402002.2015.1126596. Epub 2016 Apr 14.PMID: 27077395 Free PMC article.
14. Immune Function: Impact of Exercise and Nutritional Interventions. Kohut ML.Am J Lifestyle Med. 2016 Feb 15;10(3):174-177. doi: 10.1177/1559827616631723. eCollection 2016 May-Jun.PMID: 30202270 Free PMC article.
15. Exercise Improves Host Response to Influenza Viral Infection in Obese and Non-Obese Mice through Different Mechanisms. Warren KJ, Olson MM, Thompson NJ, Cahill ML, Wyatt TA, Yoon KJ, Loiacono CM, Kohut ML.PLoS One. 2015 Jun 25;10(6):e0129713. doi: 10.1371/journal.pone.0129713. eCollection 2015.PMID: 26110868 Free PMC article.
16. Vaccine technologies against avian influenza: current approaches and new directions.
    Ross KA, Huntimer LM, Vela Ramirez JE, Adams JR, Carpenter SL, Kohut ML, Bronich T, Webby R, Legge KL, Mallapragadal SK, Wannemuehler MJ, Narasimhan B.J Biomed Nanotechnol. 2014 Sep;10(9):2261-94. doi: 10.1166/jbn.2014.1983.PMID: 25992457 Review.
17. Alkaloids and athlete immune function: caffeine, theophylline, gingerol, ephedrine, and their congeners.
18. Senchina DS, Hallam JE, Kohut ML, Nguyen NA, Perera MA.Exerc Immunol Rev. 2014;20:68-93.PMID: 24974722 Free article. Review.
19. The immuno-regulatory impact of orally-administered Hypericum perforatum extract on Balb/C mice inoculated with H1n1 influenza A virus. Huang N, Singh N, Yoon K, Loiacono CM, Kohut ML, Birt DF.PLoS One. 2013 Sep 30;8(9):e76491. doi: 10.1371/journal.pone.0076491. eCollection 2013.PMID: 24098792 Free PMC article.
20. Enrichment of Echinacea angustifolia with Bauer alkylamide 11 and Bauer ketone 23 increased anti-inflammatory potential through interference with cox-2 enzyme activity. Lalone CA, Huang N, Rizshsky L, Yum MY, Singh N, Hauck C, Nikolau BJ, Wurtele ES, Kohut ML, Murphy PA, Birt DF.J Agric Food Chem. 2010 Aug 11;58(15):8573-84. doi: 10.1021/jf1014268.PMID: 20681645 Free PMC article.
21. Contribution of serum inflammatory markers to changes in bone mineral content and density in postmenopausal women: a 1-year investigation. Gertz ER, Silverman NE, Wise KS, Hanson KB, Alekel DL, Stewart JW, Perry CD, Bhupathiraju SN, Kohut ML, Van Loan MD.J Clin Densitom. 2010 Jul-Sep;13(3):277-82. doi: 10.1016/j.jocd.2010.04.003.PMID: 20605499 Free PMC article. Clinical Trial.
22. Is job-related stress the link between cardiovascular disease and the law enforcement profession? Franke WD, Kohut ML, Russell DW, Yoo HL, Ekkekakis P, Ramey SP.J Occup Environ Med. 2010 May;52(5):561-5. doi: 10.1097/JOM.0b013e3181dd086b.PMID: 20431405
23. Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model. Senchina DS, Flinn GN, McCann DA, Kohut ML, Shearn CT.J Herbs Spices Med Plants. 2009 Jan 1;15(1):45. doi: 10.1080/10496470902787485.PMID: 20111671 Free PMC article.
24. Effects of Echinacea extracts on macrophage antiviral activities. Senchina DS, Martin AE, Buss JE, Kohut ML.Phytother Res. 2010 Jun;24(6):810-6. doi: 10.1002/ptr.2991.PMID: 20041425
25. Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection. Sim YJ, Yu S, Yoon KJ, Loiacono CM, Kohut ML.J Infect Dis. 2009 Nov 1;200(9):1434-42. doi: 10.1086/606014.PMID: 19811098 Free PMC article.
26. Alcohol extract of Echinacea pallida reverses stress-delayed wound healing in mice.
    Zhai Z, Haney DM, Wu L, Solco AK, Murphy PA, Wurtele ES, Kohut ML, Cunnick JE.Phytomedicine. 2009 Jun;16(6-7):669-78. doi: 10.1016/j.phymed.2009.02.010. Epub 2009 Mar 20.PMID: 19303756 Free PMC article.
27. Echinacea tennesseensis ethanol tinctures harbor cytokine- and proliferation-enhancing capacities. Senchina DS, McCann DA, Flinn GN, Wu L, Zhai Z, Cunnick JE, Wurtele ES, Kohut ML.Cytokine. 2009 May;46(2):267-72. doi: 10.1016/j.cyto.2009.02.007. Epub 2009 Mar 14.PMID: 19286391 Free PMC article.
28. Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activation. Zhai Z, Solco A, Wu L, Wurtele ES, Kohut ML, Murphy PA, Cunnick JE.J Ethnopharmacol. 2009 Feb 25;122(1):76-85. doi: 10.1016/j.jep.2008.11.028. Epub 2008 Dec 7.PMID: 19111603 Free PMC article.
29. Low-level dietary deoxynivalenol and acute exercise stress result in immunotoxicity in BALB/c mice. Landgren CA, Hendrich S, Kohut ML.J Immunotoxicol. 2006 Dec 1;3(4):173-8. doi: 10.1080/15476910600979978.PMID: 18958698
30. Exercise, fitness, and neurocognitive function in older adults: the “selective improvement” and “cardiovascular fitness” hypotheses. Smiley-Oyen AL, Lowry KA, Francois SJ, Kohut ML, Ekkekakis P.Ann Behav Med. 2008 Dec;36(3):280-91. doi: 10.1007/s12160-008-9064-5. Epub 2008 Sep 30.PMID: 18825471 Free PMC article. Clinical Trial.
31. Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction. Hammer KD, Hillwig ML, Neighbors JD, Sim YJ, Kohut ML, Wiemer DF, Wurtele ES, Birt DF.Phytochemistry. 2008 Sep;69(12):2354-62. doi: 10.1016/j.phytochem.2008.06.010. Epub 2008 Aug 15.PMID: 18707743 Free PMC article.
32. Comparability of the 6-min walk test using different test configurations. Konopka del N, Shook RP, Kohut ML, Vos Tulp R, Franke WD.J Aging Phys Act. 2008 Jul;16(3):355-61. doi: 10.1123/japa.16.3.355.PMID: 18660555
33. Alcohol extracts of Echinacea inhibit production of nitric oxide and tumor necrosis factor-alpha by macrophages in vitro. Zhai Z, Haney D, Wu L, Solco A, Murphy PA, Wurtele ES, Kohut ML, Cunnick JE.Food Agric Immunol. 2007 Sep;18(3-4):221-236. doi: 10.1080/09540100701797363.PMID: 18458735 Free PMC article.
34. PHENETIC COMPARISON OF SEVEN Echinacea SPECIES BASED ON IMMUNOMODULATORY CHARACTERISTICS. Senchina DS, Flagel LE, Wendel JF, Kohut ML.Econ Bot. 2006 Sep;60(3):205-211. doi: 10.1663/0013-0001(2006)60[205:pcoses]2.0.co;2.PMID: 18301733 Free PMC article.
35. Centrally located body fat is related to inflammatory markers in healthy postmenopausal women. Perry CD, Alekel DL, Ritland LM, Bhupathiraju SN, Stewart JW, Hanson LN, Matvienko OA, Kohut ML, Reddy MB, Van Loan MD, Genschel U.Menopause. 2008 Jul-Aug;15(4 Pt 1):619-27. doi: 10.1097/gme.0b013e318159f1a2.PMID: 18202591 Free PMC article.
36. Immunological outcomes of exercise in older adults. Senchina DS, Kohut ML.Clin Interv Aging. 2007;2(1):3-16. doi: 10.2147/ciia.2007.2.1.3.PMID: 18044072 Free PMC article. Review.
37. Enhancement of innate and adaptive immune functions by multiple Echinacea species. Zhai Z, Liu Y, Wu L, Senchina DS, Wurtele ES, Murphy PA, Kohut ML, Cunnick JE.J Med Food. 2007 Sep;10(3):423-34. doi: 10.1089/jmf.2006.257.PMID: 17887935 Free PMC article.
38. Cytokine- and interferon-modulating properties of Echinacea spp. root tinctures stored at -20 degrees C for 2 years. McCann DA, Solco A, Liu Y, Macaluso F, Murphy PA, Kohut ML, Senchina DS.J Interferon Cytokine Res. 2007 May;27(5):425-36. doi: 10.1089/jir.2006.0104.PMID: 17523874 Free PMC article.
39. Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. Hanson LN, Engelman HM, Alekel DL, Schalinske KL, Kohut ML, Reddy MB.Am J Clin Nutr. 2006 Oct;84(4):774-80. doi: 10.1093/ajcn/84.4.774.PMID: 17023703 Free article. Clinical Trial.
40. Year-and-a-half old, dried Echinacea roots retain cytokine-modulating capabilities in an in vitro human older adult model of influenza vaccination. Senchina DS, Wu L, Flinn GN, Konopka del N, McCoy JA, Widrlechner MP, Wurtele ES, Kohut ML.Planta Med. 2006 Oct;72(13):1207-15. doi: 10.1055/s-2006-947254. Epub 2006 Oct 4.PMID: 17021999 Free PMC article.
41. Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Kohut ML, McCann DA, Russell DW, Konopka DN, Cunnick JE, Franke WD, Castillo MC, Reighard AE, Vanderah E.Brain Behav Immun. 2006 May;20(3):201-9. doi: 10.1016/j.bbi.2005.12.002. Epub 2006 Feb 28.PMID: 16504463 Clinical Trial.
42. The exercise-induced enhancement of influenza immunity is mediated in part by improvements in psychosocial factors in older adults. Kohut ML, Lee W, Martin A, Arnston B, Russell DW, Ekkekakis P, Yoon KJ, Bishop A, Cunnick JE.Brain Behav Immun. 2005 Jul;19(4):357-66. doi: 10.1016/j.bbi.2004.12.002.PMID: 15944076 Clinical Trial.
43. Glucocorticoids produced during exercise may be necessary for optimal virus-induced IL-2 and cell proliferation whereas both catecholamines and glucocorticoids may be required for adequate immune defense to viral infection.
    Kohut ML, Martin AE, Senchina DS, Lee W.Brain Behav Immun. 2005 Sep;19(5):423-35. doi: 10.1016/j.bbi.2005.04.006.PMID: 15935613
44. Changes in immunomodulatory properties of Echinacea spp. root infusions and tinctures stored at 4 degrees C for four days.
45. Senchina DS, McCann DA, Asp JM, Johnson JA, Cunnick JE, Kaiser MS, Kohut ML.Clin Chim Acta. 2005 May;355(1-2):67-82. doi: 10.1016/j.cccn.2004.12.013.PMID: 15820480
46. Mood and cytokine response to influenza virus in older adults.
47. Costanzo ES, Lutgendorf SK, Kohut ML, Nisly N, Rozeboom K, Spooner S, Benda J, McElhaney JE.J Gerontol A Biol Sci Med Sci. 2004 Dec;59(12):1328-33. doi: 10.1093/gerona/59.12.1328.PMID: 15699534
48. Reversing age-associated immunosenescence via exercise. Kohut ML, Senchina DS.Exerc Immunol Rev. 2004;10:6-41.PMID: 15633584 Free article. Review.
49. Age effects on macrophage function vary by tissue site, nature of stimulant, and exercise behavior. Kohut ML, Senchina DS, Madden KS, Martin AE, Felten DL, Moynihan JA.Exp Gerontol. 2004 Sep;39(9):1347-60. doi: 10.1016/j.exger.2004.07.001.PMID: 15489058
50. Moderate exercise improves antibody response to influenza immunization in older adults.
    Kohut ML, Arntson BA, Lee W, Rozeboom K, Yoon KJ, Cunnick JE, McElhaney J.Vaccine. 2004 Jun 2;22(17-18):2298-306. doi: 10.1016/j.vaccine.2003.11.023.PMID: 15149789 Clinical Trial.
51. Exercise training-induced adaptations of immune response are mediated by beta-adrenergic receptors in aged but not young mice. Kohut ML, Thompson JR, Lee W, Cunnick JE.J Appl Physiol (1985). 2004 Apr;96(4):1312-22. doi: 10.1152/japplphysiol.00792.2003. Epub 2003 Dec 12.PMID: 14672970 Free article.
52. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. Kohut ML, Thompson JR, Campbell J, Brown GA, Vukovich MD, Jackson DA, King DS.J Am Coll Nutr. 2003 Oct;22(5):363-71. doi: 10.1080/07315724.2003.10719319.PMID: 14559928 Clinical Trial.
53. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. Kohut ML, Cooper MM, Nickolaus MS, Russell DR, Cunnick JE.J Gerontol A Biol Sci Med Sci. 2002 Sep;57(9):M557-62. doi: 10.1093/gerona/57.9.m557.PMID: 12196490
54. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, King DS.Int J Vitam Nutr Res. 2001 Sep;71(5):293-301. doi: 10.1024/0300-9831.71.5.293.PMID: 11725694 Free article. Clinical Trial.
55. Endocrine and lipid responses to chronic androstenediol-herbal supplementation in 30 to 58 year old men. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, King DS.J Am Coll Nutr. 2001 Oct;20(5):520-8. doi: 10.1080/07315724.2001.10719061.PMID: 11601567 Clinical Trial.
56. Moderate exercise is associated with enhanced antigen-specific cytokine, but not IgM antibody production in aged mice. Kohut ML, Boehm GW, Moynihan JA.Mech Ageing Dev. 2001 Aug;122(11):1135-50. doi: 10.1016/s0047-6374(01)00255-x.PMID: 11389929
57. Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection. Kohut ML, Boehm GW, Moynihan JA.J Appl Physiol (1985). 2001 Feb;90(2):678-84. doi: 10.1152/jappl.2001.90.2.678.PMID: 11160069 Free article.
58. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. Brown GA, Vukovich MD, Martini ER, Kohut ML, Franke WD, Jackson DA, King DS.J Clin Endocrinol Metab. 2000 Nov;85(11):4074-80. doi: 10.1210/jcem.85.11.6940.PMID: 11095435 Clinical Trial.
59. Exercise effects on IFN-beta expression and viral replication in lung macrophages after HSV-1 infection. Kohut ML, Davis JM, Jackson DA, Jani P, Ghaffar A, Mayer EP, Essig DA.Am J Physiol. 1998 Dec;275(6):L1089-94. doi: 10.1152/ajplung.1998.275.6.L1089.PMID: 9843845
60. Immune system activation and fatigue during treadmill running: role of interferon. Davis JM, Weaver JA, Kohut ML, Colbert LH, Ghaffar A, Mayer EP.Med Sci Sports Exerc. 1998 Jun;30(6):863-8. doi: 10.1097/00005768-199806000-00014.PMID: 9624644
61. Exercise effects on lung tumor metastases and in vitro alveolar macrophage antitumor cytotoxicity. Davis JM, Kohut ML, Jackson DA, Colbert LH, Mayer EP, Ghaffar A.Am J Physiol. 1998 May;274(5):R1454-9. doi: 10.1152/ajpregu.1998.274.5.R1454.PMID: 9612414
62. The role of stress hormones in exercise-induced suppression of alveolar macrophage antiviral function. Kohut ML, Davis JM, Jackson DA, Colbert LH, Strasner A, Essig DA, Pate RR, Ghaffar A, Mayer EP.J Neuroimmunol. 1998 Jan;81(1-2):193-200. doi: 10.1016/s0165-5728(97)00179-3.PMID: 9521622
63. Exercise, alveolar macrophage function, and susceptibility to respiratory infection.
    Davis JM, Kohut ML, Colbert LH, Jackson DA, Ghaffar A, Mayer EP.J Appl Physiol (1985). 1997 Nov;83(5):1461-6. doi: 10.1152/jappl.1997.83.5.1461.PMID: 9375306 Free article.
64. Effects of exercise intensity on natural killer cell activity in women. Strasner A, Davis JM, Kohut ML, Pate RR, Ghaffar A, Mayer E.Int J Sports Med. 1997 Jan;18(1):56-61. doi: 10.1055/s-2007-972595.PMID: 9059906
65. Effects of exercise on the immune response to cancer. Woods JA, Davis JM, Kohut ML, Ghaffar A, Mayer EP, Pate RR.Med Sci Sports Exerc. 1994 Sep;26(9):1109-15.PMID: 7808244

NIH R01 AI154458-01