RESEARCH

Combination nanovaccine-based immunization against influenza the aged: immunity and protection.

The goal of this proposal is to identify the effect of vaccine biomaterials and adjuvants on dendritic cell metabolism, and subsequent effects on antibody and T cell memory to develop a nanovaccine to overcome age-related immune impairments.

NIH R01 AI154458-01

Adjuvant effect of physical exercise on immune response to COVID-19 vaccination and interactions with stress.

The goals of this project are to determine how exercise applied at the time of initial immunization to SARS-CoV-2 virus impacts immune response, establish the effect of psychological stress on immunogenicity to vaccination, and identify potential operative mechanisms

NIH R21 AI169330-02

Applying gene transcription findings from a protective phenotype in drug discovery against influenza virus.

Using gene expression findings from lung of exercise-training induced protection against influenza, potential novel antiviral proteins are evaluated for ability to restrict viral replication in A549 lung epithelial cells and mouse influenza infection models.

NIH R21 AI169330-02