Combination nanovaccine-based immunization against influenza the aged: immunity and protection.
The goal of this proposal is to identify the effect of vaccine biomaterials and adjuvants on dendritic cell metabolism, and subsequent effects on antibody and T cell memory to develop a nanovaccine to overcome age-related immune impairments.
NIH R01 AI154458-01
Adjuvant effect of physical exercise on immune response to COVID-19 vaccination and interactions with stress.
The goals of this project are to determine how exercise applied at the time of initial immunization to SARS-CoV-2 virus impacts immune response, establish the effect of psychological stress on immunogenicity to vaccination, and identify potential operative mechanisms
NIH R21 AI169330-02
Applying gene transcription findings from a protective phenotype in drug discovery against influenza virus.
Using gene expression findings from lung of exercise-training induced protection against influenza, potential novel antiviral proteins are evaluated for ability to restrict viral replication in A549 lung epithelial cells and mouse influenza infection models.
NIH R21 AI169330-02
