Our goal is to determine the genes and mechanisms that underlie the pathobiology of nervous system disorders – across the lifespan.

We take advantage of multiple cutting-edge genomic technologies together with anatomical analyses to study the human brain at unprecedented resolution, complementing these studies in rodent and in vitro models. Much of our focus is centered on the developing cerebellum. Cerebellar birth defects are recognized as central to many neurodevelopmental disorders, including autism and intellectual disability. We also study stem cell biology in the cerebral cortex in the context of epilepsy and aging.